At VIRUN, our scientists create new formulas with an ever-expanding range of active nutrients. Explore the latest efficacious blends to have your customers coming back for more.
We are introducing 3 new nutrient blends: Magnesium Glycerophosphate, a stabilized NAD + with Glutathione, and a Glycerol with GABA.
A New Magnesium
Magnesium Glycerophosphate is a highly bioavailable form of magnesium that is proven to improve: sleep and relaxation, muscle function and recovery, bone density, and blood sugar levels. We favor Magnesium Glycerophosphate because of its higher solubility and elevated absorption in the gastrointestinal tract compared with other forms of magnesium. This means that it is easier to formulate with, and delivers efficacious and perceived benefits.
Why formulate with Magnesium Glycerophosphate?
Magnesium deficiency is prevalent amongst 10% to 30% of the world’s population, particularly amongst populations who consume a diet predominantly of processed food.[1] Magnesium is an essential electrolyte that allows the nervous system[2] to function properly. Magnesium regulates neurotransmitters and activates the parasympathetic nervous system, optimizing sleep and relaxation, even amongst insomniacs.[3]
Magnesium supplements are ideal for athletes’ muscle recovery and function[4], as well as for supporting cardiovascular health. Magnesium Glycerophosphate ensures that an adequate amount of magnesium reaches muscle tissues efficiently. Magnesium is critical for maintaining a healthy heart rhythm. It acts as a natural calcium antagonist, helping to regulate blood pressure and prevent hypertension. In addition, magnesium supports the regulation of calcium levels in the bones.[5] Magnesium contributes to higher bone mineral density and a lower risk of osteoporosis.
Magnesium offers metabolic benefits too, playing a role in glucose metabolism and insulin sensitivity. Higher magnesium intake has been correlated with a lower risk of type 2 diabetes.
Magnesium Glycerophosphate, due to its efficient absorption, can be more effective in delivering all of the above benefits compared to its less bioavailable counterparts.
Stabilized NAD+ complements Glutathione
Coveted by anti-aging and longevity enthusiasts, NAD+ has been out of reach in supplement form, until now.
We have successfully formulated a stable NAD+ that works effectively in isolation, yet also works in synergy with Glutathione. This efficacious blend allows you to deliver pioneering anti-aging, cellular regenerative and DNA protective benefits that longevity focused consumers will love.
Why formulate with NAD+?
As a standalone ingredient, NAD+ offers optimized cellular and mitochondrial function, boosting vitality as we age.[6] NAD+ supports the repair of damaged DNA.[7] Damaged DNA can lead to gene mutations and the growth of cancer cells over time. Thus, the genomic stability that NAD+ maintains is essential for longevity[8]and cancer prevention. NAD+ activates sirtuins, including SIRT1, which positively influences mitochondrial function, inflammation and stress resistance. SIRT1 activation is linked to increased lifespan. [9] NAD+ further reduces chronic inflammation—correlated with many western world diseases, including cardiovascular disease[10], diabetes and Alzheimer’s.
Why combine Anti-Aging NAD+ with the Super Antioxidant Glutathione?
Glutathione[11] is the body’s most powerful antioxidant, crucial for neutralizing free radicals and preventing oxidative damage. NAD+ assists in the regeneration of glutathione from its oxidized form (GSSG) back to its reduced form (GSH), thereby maintaining its antioxidant capacity. Together, NAD+ and glutathione effectively reduce oxidative stress, which is a significant contributor to aging.
Glutathione and NAD+ enhance the body’s ability to detoxify harmful substances. Both compounds are critical for mitochondrial health, NAD+ supports mitochondrial function[12] and energy production, while glutathione protects mitochondria from oxidative damage. Healthy mitochondria are essential for energy production, metabolic health, and preventing the degenerative symptoms associated with aging. Finally, NAD+ supports the production of immune cells whilst glutathione protects the immune cells from oxidative damage. In unison, they protect and repair the immune system, fortifying immunity and preventing age-related immune decline.
A truly powerful anti-aging supplement synergy that is far more stable and bioavailable when delivered in lipid emulsified form.
Glycerol activates GABA
When administered in isolation, oral GABA supplementation has a low bioavailability rate—despite the growth of GABA products in the supplement market. However, Glycerol enhances GABA[13] levels in the brain, so that the individual can really experience the calming effects of GABA.
GABA supports relaxation and a sense of calm by inhibiting the release of adrenaline and norepinephrine, the excitatory neurotransmitters.
The mechanisms of glycerol metabolism in the brain allow for increased uptake and synthesis of GABA by GABAergic neurons.[14] Thus, glycerol makes GABA supplements more effective at optimizing sleep and relaxation, focus and cognitive function.
Be the first to formulate a GABA supplement (with Glycerol) that delivers real calm.
Our recommended formula to consider:
Glycerol, GABA (PharmaGABA is natural GABA), Tryptophan, Glutamate and Glycine (Brain neurotransmitter to modulate decrease in Dopamine, GABA and Serotonin as these are depleted) and maybe the Mg Glycerophosphate, unless you want to keep current Mg separate).
Get in touch today to formulate incredible supplements with us.
REFERENCES:
[1]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786912 Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis
[2] “Magnesium in the Central Nervous System” (2011). Vink R, Nechifor M, editors. Adelaide (AU): University of Adelaide Press.
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703169/ The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial
[4] https://pubmed.ncbi.nlm.nih.gov/33009349/ Effects of Magnesium Supplementation on Muscle Soreness and Performance
[5] “Dietary magnesium and cardiovascular disease: a review with emphasis in epidemiological studies” (2013). Andrea Rosanoff, Ph.D., et al. Journal of Biomedical Science.
[6] Yoshino, J., Baur, J. A., & Imai, S. I. (2018). NAD+ intermediates: The biology and therapeutic potential of NMN and NR. Cell Metabolism, 27(3), 513-528. doi:10.1016/j.cmet.2017.11.002
[7] Verdin, E. (2015). NAD+ in aging, metabolism, and neurodegeneration. Science, 350(6265), 1208-1213. doi:10.1126/science.aac4854
[8] Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology, 22(2), 119-141. doi:10.1038/s41580-020-00313-x
[9] Lifespan: Why We Age and Why We Don’t Have To, David A. Sinclair
[10] The Role of Inflammation in Cardiovascular Disease https://pubmed.ncbi.nlm.nih.gov/36361701/
[11] Forman, H. J., & Zhang, H. (2021). Glutathione: Overview of its protective roles, measurement, and biosynthesis. Molecular Aspects of Medicine, 83, 100-105. doi:10.1016/j.mam.2021.100105
[12] Johnson, S., Imai, S. I. (2018). NAD+ biosynthesis, aging, and disease. F1000Research, 7. doi:10.12688/f1000research.15988.1
[13] Physiology and Pharmacology of the GABA System: Focus on GABA Receptors
https://link.springer.com/chapter/10.1007/978-3-0346-0226-6_1
[14]Nguyen, N.H.T., Bråthe, A., & Hassel, B. (2003). Neuronal uptake and metabolism of glycerol and the neuronal expression of mitochondrial glycerol‐3‐phosphate dehydrogenase. Journal of Neurochemistry, 85(3), 831-842. doi:10.1046/j.1471-4159.2003.01762.
